N VITRO in Patients with Non-Infectious Uveitis and Viral Keratitis

Authors: H. S. Fesyunova, L. M. Velychko, O. V. Bohdanova, S. M. Kisil, H. M. Tsybuliak

Background: The development of an ocular pharmaceutical form based on aloe polysaccharides, which to some extent determine the high biological activity of this plant, is a relevant and promising direction in pharmacology.

Purpose: To investigate the in vitro expression levels of molecular markers related to CD5+ activation and CD54+ intercellular adhesion on lymphocytes from peripheral blood in patients with non-infectious uveitis and viral keratitis under the influence of aloe polysaccharide extract and aqueous aloe extract.

Materials and Methods: The study determined the absolute and relative expression levels of adhesion and autoaggression markers (CD54+, CD5+) on lymphocytes from peripheral blood of patients with acute non-infectious uveitis and acute viral keratitis after incubation with aloe polysaccharide extract and aqueous aloe extract. Patients were divided into two groups: Group 1 included 10 patients with ocular vascular tract inflammation (non-infectious uveitis), and Group 2 included 17 patients with viral keratitis. The patients’ age was 49.87±3.89 years. The control group consisted of 20 healthy donors of similar age.

For more details, refer to the Journal of Ophthalmology, vol. №2, 2024.