Results of reconstructive operations in orbit and oculoorbital area with the help of developed implants (polymer composite and cross-linked polyurethane)
Injuries of the facial skeleton in combination with the visual organ range
from 36 to 64%, while 64.5% are domestic injuries, 21.7% - criminal and 15.5% -
The social significance of eyelid, orbit and oculoorbital injuries is
determined by young working age of patients, while bimodal distributions of
orbit contusion are observed with frequency peaks at the age
of 16-21 and 39-55 years, which leads, in 89% of cases, to
a decrease in adaptation of the patient to work.
The use of biological tissues in reconstructive surgery does not always
satisfy the surgeon, in addition, legal requirements for the collection of
donor material increase every year. The creation of synthetic polymeric
materials for the repair of anatomical and functional damage is an urgent task.
Specialists of SI "The Filatov Institute of Eye Diseases and Tissue
Therapy of NAMS of Ukraine," the Institute of High-Molecular Compounds
Chemistry of the NASciences of Ukraine and the Institute of General and
Inorganic Chemistry of NAS of the Republic of Belarus have developed
biocompatible implants based on cross-linked polyurethane with biological
active substances (albucide, dacarbazine) and polymer composite (PC).
Clinical studies have shown that the developed carbon polymer implant has inertia
to soft biological tissues, lack of tendency to resorption, prevents the
formation of adhesions between the eye and walls of the orbit, can also be used
to replace resorbed soft tissues. It should be emphasized, that the developed
implant can be modeled well, which allows adjusting its shape during surgery. A
significant disadvantage of the carbon polymer material is dark, which is
visible through thin layers of soft tissues.
Preliminary studies (during 4 months) of usage in clinical practice of cross-linked
polyurethane with biological active substances (albucide, dacarbazine) make it
possible to conclude that the implant, we have developed, from polyurethane has
good biocompatibility and germinates well with surrounding tissues. The effect
of dacarbazine immobilized in the implant on prolonged tumor growth in orbital
tissues requires analysis of distant results.